中文名稱：CDKN1B抗原（重組蛋白）

英文名稱：CDKN1B Antigen (Recombinant Protein)

儲存：冷凍（-20℃）

相關(guān)類別：抗原

概述

Fusion protein corresponding to a region derived from 1-198 amino acids of human CDKN1B

技術(shù)規(guī)格

Full name:

cyclin dependent kinase inhibitor 1B

Synonyms:

KIP1; MEN4; CDKN4; MEN1B; P27KIP1

Swissprot:

P46527

Gene Accession:

BC001971

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).

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CDKN1B抗原（重組蛋白）說明書
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CDKN1B抗原（重組蛋白）

Full name:	cyclin dependent kinase inhibitor 1B
Synonyms:	KIP1; MEN4; CDKN4; MEN1B; P27KIP1
Swissprot:	P46527
Gene Accession:	BC001971
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).