Name: MAPK8抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： MAPK8抗原（重組蛋白）

英文名稱： MAPK8 Antigen (Recombinant Protein)

別名： JNK; JNK1; PRKM8; SAPK1; JNK-46; JNK1A2; SAPK1c; JNK21B1/2

儲存： 冷凍（-20℃）

相關(guān)類別： 抗原

概述

Fusion protein corresponding to a region derived from 128-427 amino acids of human MAPK8

技術(shù)規(guī)格

Full name:	mitogen-activated protein kinase 8
Synonyms:	JNK; JNK1; PRKM8; SAPK1; JNK-46; JNK1A2; SAPK1c; JNK21B1/2
Swissprot:	P45983
Gene Accession:	BC130570
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.

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