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    • 品牌 :
    • 目錄號 : TW2997
    • 應用 : 僅用于科研使用
    • 貨期 : 現貨
    • 規格 :100ul/200ul/25ul
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中文名稱:兔抗ATXN7多克隆抗體  

英文名稱: Anti-ATXN7 rabbit polyclonal antibody

別      名: ataxin 7; SCA7; OPCA3; ADCAII

相關類別: 一抗

儲      存: 冷凍(-20℃)

宿      主: Rabbit

抗      原: ATXN7

反應種屬: Human, Mouse

標 記 物: Unconjugate

克隆類型: rabbit polyclonal

技術規格

Background:

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the 'pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with spinocerebellar ataxia-7 contains 38-130 CAG repeats (near the N-terminus), compared to 7-17 in the normal allele. The encoded protein is a component of the SPT3/TAF9/GCN5 acetyltransferase (STAGA) and TBP-free TAF-containing (TFTC) chromatin remodeling complexes, and it thus plays a role in transcriptional regulation. Alternative splicing results in multiple transcript variants.

Applications:

ELISA, IHC

Name of antibody:

ATXN7

Immunogen:

Synthetic peptide of human ATXN7

Full name:

ataxin 7

Synonyms:

SCA7; OPCA3; ADCAII

SwissProt:

O15265

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and human lung cancer

IHC Recommend dilution:

50-300





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