Name: TP53 抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： TP53 抗原（重組蛋白）

英文名稱： TP53 Antigen (Recombinant Protein)

相關(guān)類別：抗原

儲(chǔ) 存：冷凍（-20℃）

概述

Fusion protein corresponding to a region derived from 1-233 amino acids of human TP53

技術(shù)規(guī)格

Full name:	tumor protein p53
Synonyms:	P53; BCC7; LFS1; TRP53
Swissprot:	P04637
Gene Accession:	BC003596
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants.

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