購(gòu)物車
幫助
021-54845833/15800441009
中文名稱： 兔抗PPP4R2多克隆抗體
英文名稱： Anti-PPP4R2 rabbit polyclonal antibody
別 名： PP4R2
相關(guān)類別： 一抗
儲(chǔ) 存： 冷凍（-20℃） 避光
宿 主： Rabbit
抗 原： PPP4R2
反應(yīng)種屬： Human Mouse
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. |
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Applications: |
WB |
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Name of antibody: |
PPP4R2 |
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Immunogen: |
Synthesized peptide derived from internal of human PP4R2. |
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Full name: |
protein phosphatase 4, regulatory subunit 2 |
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Synonyms： |
PP4R2 |
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SwissProt: |
Q9NY27 |
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WB Predicted band size: |
47 kDa |
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WB Positive control: |
K562 cells and COS7 cells lysates |
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WB Recommended dilution: |
500-3000 |
