購(gòu)物車
幫助
021-54845833/15800441009
中文名稱：BMI1抗原（重組蛋白）
英文名稱： BMI1 Antigen (Recombinant Protein)
別 名： PCGF4; RNF51; FLVI2/BMI1
儲(chǔ) 存： 冷凍（-20℃）
相關(guān)類別： 抗原
概 述：
|
Fusion protein corresponding to N terminal 250 amino acids of human BMI1 |
|
Full name: |
BMI1 polycomb ring finger oncogene |
|
Synonyms: |
PCGF4; RNF51; FLVI2/BMI1 |
|
Swissprot: |
P35226 |
|
Gene Accession: |
BC011652 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
BMI1 polycomb ring finger oncogene, also known as BMI1, is a protein which in humans is encoded by the BMI1gene. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. |
