Name: 小鼠抗PTGES3單克隆抗體
Brand: 通蔚生物

中文名稱：小鼠抗PTGES3單克隆抗體

英文名稱： Anti-PTGES3 mouse monoclonal antibody

別名： cPGES; P23; TEBP

相關(guān)類別：一抗

儲(chǔ) 存： 冷凍（-20℃）避光

宿主： Mouse

抗原： PTGES3

反應(yīng)種屬： Human

標(biāo) 記物： Unconjugate

克隆類型： mouse monoclonal

技術(shù)規(guī)格

Background:	P23, also known as PTGES3 (prostaglandin E synthase 3) or TEBP (telomerase-binding protein p23), is a ubiquitously expressed protein that functions as a cochaperone and plays an important role in signal transduction. One of several proteins in the HSP 90-based molecular chaperone complex, P23 promotes the breakdown of transcriptional regulatory complexes by disrupting receptor-mediated transcriptional activation. P23 acts in a hormone-dependent manner to chaperone estrogen receptor alpha (ER ), a steroid complex, to its mature form and to regulate the expression of ER -related genes. Localized to the cytoplasm, P23 interacts with the glucocorticoid receptor (GR) and, through disassembly of the GR transcription machinery, is thought to inhibit GR-dependent transcription. The involvement of P23 in various steroid receptor-mediated pathways suggests close involvement in signal transduction and regulation of cellular processes. Upregulation of P23 is implicated in the invasion and metastasis of various cancers.
Applications:	WB, IHC
Name of antibody:	PTGES3
Immunogen:	Fusion protein of human PTGES3
Full name:	prostaglandin E synthase 3 (cytosolic) (PTGES3), transcript variant 1
Synonyms:	cPGES; P23; TEBP
SwissProt:	Q15185
IHC positive control:	adenocarcinoma of human ovary tissue
IHC Recommend dilution:	30-150
WB Predicted band size:	19 kDa
WB Positive control:	A549 cell lysate
WB Recommended dilution:	500-2000

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